In nucleophilic substitution reactions (SN2), one group, called the leaving group, is exchanged for another, called the nucleophile.

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[1] Substrate - Species containing the leaving group
[2] Nucleophile - Lewis base capable of attacking atoms with positive polarity (or charge)
[3] Reaction product
[4] Leaving group - Species that leaves the substrate, being replaced by the nucleophile


Nucleophilic substitution reactions allow many organic compounds to be obtained from alkyne halides. Let's see some examples:

a) The reaction of bromoethane with sodium hydroxide produces ethanol.

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b) The reaction of isopropyl chloride with sodium cyanide produces a nitrile

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c) The reaction of iodomethane with sodium methoxide produces an ether (dimethyl ether)

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d) Amines can be obtained by reacting ammonia with haloalkanes

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In these examples the leaving group is represented in red and the nucleophile in blue.