Mannich prepares 3-aminocarbonyls from primary or secondary amines, methane, and an enolizable carbonyl. Let's see an example:
![reaction-mannich reaccion-mannich](/images/stories/organica-ii/aminas/mannich/reaccion-mannich-01.png)
The Mannich mechanism takes place in the following steps:
Step 1 . Formation of the immonium cation
![reaction-mannich reaccion-mannich](/images/stories/organica-ii/aminas/mannich/reaccion-mannich-02.png)
Step 2. Enolization of the carbonyl
![reaction-mannich reaccion-mannich](/images/stories/organica-ii/aminas/mannich/reaccion-mannich-03.png)
Step 3. Condensation of the enol with the immonium cation
![reaction-mannich reaccion-mannich](/images/stories/organica-ii/aminas/mannich/reaccion-mannich-04.png)
Step 4. Hydrochloride formation
![reaction-mannich reaccion-mannich](/images/stories/organica-ii/aminas/mannich/reaccion-mannich-05.png)
Step 5. Neutralization of the acid medium
![reaction-mannich reaccion-mannich](/images/stories/organica-ii/aminas/mannich/reaccion-mannich-06.png)