Lactams are cyclic amides obtained by condensation, with loss of water, of a molecule containing acid and amino groups.

4-(aminomethyl)butanoic acid [1] condenses under heating to form N-methylpyrrolidin-2-one [2] , a polar aprotic solvent.

The lactam ring appears in numerous compounds with biological activity, such as penicillins and cephalosporins. The peniciclin G molecule is drawn below.


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