molecular-model-pyridine The pyridine molecule can be obtained by reacting enamines with a,b-unsaturated. Thus, the reaction between ethenamine and propenal, followed by oxidation, produces pyridine.

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The following lines detail the synthesis mechanism:

Stage 1. Nucleophilic attack of the enamine on the a,b-unsaturated

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Stage 2. Acid-base balance

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Stage 3. Keto-enol tautomerism

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Stage 4. Imine-enamine tautomerism

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Step 5. Cyclization by nucleophilic addition of the amino to the carbonyl

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Stage 6. Acid-base balance

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Step 7. Elimination of the hydroxyl

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Stage 8. Elimination

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