deprotonation of phthalimide.
nucleophilic substitution
deprotonation of the diester
rent.
Hydrolysis of imide and diester
Decarboxylation of 1,3-diacid.
Amino Acid Synthesis - Gabriel
- Details
- Germán Fernández
- AMINO ACIDS AND PEPTIDES THEORY
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In this synthesis, the phthalimide salt is reacted with the halogenated malonic ester. In later stages it is alkylated, hydrolyzed and decarboxylated, obtaining the amino acid.
