This is a widely used method for preparing amino acids in the laboratory. Ethanamide amidate is reacted with the halogenated malonium ester , obtaining the compound which is alkylated and hydrolyzed to give a diacid , which decarboxylates to form the amino acid .
![synthesis-amino acids-malonica sintesis-aminoacidos-malonica](/images/stories/organica-avanzada/productos-naturales/aminoacidos-peptidos/sintesis-malonica/sintesis-aminoacidos-malonica-01.png)