AMINO ACIDS AND PEPTIDES THEORY
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- German Fernandez
- AMINO ACIDS AND PEPTIDES THEORY
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Amino acids are organic compounds that contain carboxylic acid and amino functions. Two amino acids can be joined under suitable conditions, through an amide bond, forming a dipeptide. The dipeptide can incorporate a third amino acid, forming a tripeptide. Chains with more than 50 amino acids are called proteins.

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- German Fernandez
- AMINO ACIDS AND PEPTIDES THEORY
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- German Fernandez
- AMINO ACIDS AND PEPTIDES THEORY
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The presence of acid (-COOH) and basic (-NH 2 ) groups gives amino acids characteristic acid-base properties.
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- German Fernandez
- AMINO ACIDS AND PEPTIDES THEORY
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Amino acids can be obtained by halogenation of carboxylic acids, followed by nucleophilic substitution with ammonia. The halogenation of the a position of the carboxylic acid is carried out with the Hell-Volhard-Zelinsky reaction.
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- German Fernandez
- AMINO ACIDS AND PEPTIDES THEORY
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- German Fernandez
- AMINO ACIDS AND PEPTIDES THEORY
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This is a widely used method for preparing amino acids in the laboratory. Ethanamide amidate [1] with the halogenated malonic ester [2] , obtaining the compound [3] that is alkylated and hydrolyzed giving a diacid [6] , which decarboxylates to form the amino acid [7] .
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- German Fernandez
- AMINO ACIDS AND PEPTIDES THEORY
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The Strecker synthesis allows obtaining amino acids from aldehydes or ketones.

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- German Fernandez
- AMINO ACIDS AND PEPTIDES THEORY
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- German Fernandez
- AMINO ACIDS AND PEPTIDES THEORY
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The amino group is protected to prevent its reaction with the acid group of the second amino acid. Once the peptide bond is formed, deprotection is performed, again leaving the amino group free.

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- German Fernandez
- AMINO ACIDS AND PEPTIDES THEORY
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The acid group is protected by transforming it into an ester by reaction with an alcohol. Methyl, ethyl or tert -butyl esters are prepared by esterification and hydrolyzed (deprotected) in a basic medium.

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- German Fernandez
- AMINO ACIDS AND PEPTIDES THEORY
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The synthesis of the dipeptide Glycine-Alanine (Gly-Ala) takes place through the formation of the amide (peptide) bond between the acid group of Glycine and the amino group of alanine. Therefore, it is necessary to protect the amino group of Glycine and the acid of alanine.
