Mannich reaction of pyrrole

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PYRROL, THIOPHENE AND FURAN THEORY
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The Mannich reaction allows placing the aminomethyl group on position 2 of the pyrrole.

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Mechanism:

Stage 1. Formation of the Mannich electrophile

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Stage 2. Nucleophilic attack of pyrrole on the Mannich electrophile

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Stage 3. Recovery of aromaticity

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Stage 4. Neutralization

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