The Paal-Knorr synthesis generates thiophenes by reaction of 1,4-dicarbonyls with P 4 S 10
Stage 1. Formation of the thiocarbonyl
Stage 2. Formation of the enothiol
Stage 3. Cyclization
Stage 4. Dehydration
The Paal-Knorr synthesis generates thiophenes by reaction of 1,4-dicarbonyls with P 4 S 10
Stage 1. Formation of the thiocarbonyl
Stage 2. Formation of the enothiol
Stage 3. Cyclization
Stage 4. Dehydration