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Reformatsky 1 year 6 months ago #13619

Good evening,
I'm looking at the Reformatsky reaction, I see that Zn attacks C alpha (delta) bonded to a halogen (delta -), but immediately afterwards it is attacked by the pi bond between O and the carbonyl of another molecule lo Which would imply one of the + of Zn, would this delta + be caused by the inductive effect of the halogen that has been displaced to join the Zn?
All the best

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Reformatsky 1 year 6 months ago #13623

Actually, Zn, which has a great affinity for carbonyl oxygen, coordinates with it, producing displacement of the halide as a good leaving group, in such a way that the Zn enolate is formed, which, as we already know from enolate chemistry, attacks/ reacts through carbon the alpha as nucleophile against the
attached carbonyl compound T picture of the mechanism
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Last Edit: by elenaa123 .
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