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shannonb
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Good evening, I would like to know if you can guide me with the retrosynthetic analysis and the synthesis of the following molecule, from ortho-phenylenediamine and commercial reagents... thank you very much.
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wilbertrivera
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Hello foreigner.
I propose a retrosynthetic analysis of the target molecule. I do not write the reactions, because they come from the same scheme. So you start with a Friedel Crafts acylation, on benzene, followed by a condensation in a basic medium in excess of the aldol type between two molecules of acetophenone, to which o-phenylenediamine is added, to reach the target molecule.
Greetings.
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shannonb
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THANK YOU SO MUCH WILBERT!
you are seriously an expert! I also did something similar in a few steps, if you can see it and correct it for me it would be great and thank you again. psdt: I hope you understand the mess.
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wilbertrivera
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Hello Forera.
A disconnection is correct, basically if: a) A chemical reaction that forms the disconnected link is clearly established. b) The synthons generated from the disconnection can be represented by synthetic equivalents, which contain said synthon. For this reason, if you review your first disconnection and the equivalents that you propose, the aforementioned conditions are not met. Greetings.
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sudsy124
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Excuse me, I would like you to guide me also with the following retrosynthetic analysis
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wilbertrivera
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Hi Forumer.
It would have been interesting if you could create another post. At your request, I present to you a retrosynthesis option. I leave the synthesis to your contribution.
Greetings
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