ISSUE:

hello everyone again!!! I would like to see if someone can help me with the retrosynthesis of clopidogrel.







thank you so much!!!
greetings!!

Hello Martin, I indicate a possible retrosynthesis, try to make the corresponding synthesis.



Greetings

Hello Martin.

I make other retrosynthesis proposals for racemic clopidogrel, which take different options from the one analyzed by Germán, so that they do not remain on file and help someone who would like to explore them in the laboratory. I do not know the yields. Greetings.

Good evening, could you help me with the explanation of clopidrogel retrosynthesis please!!!!!! pls......thank you

You can explain the first two steps of the retrosynthesis, that is to say, in the synthesis strecker occurs by adding a salt from with cn and then it goes from cn to cooh and then it is esterified but then how the amine joins with the tosylate and then how the amine is closed cycle.

Hello!
The cycle is closed by a Mannich reaction. The methanal forms an immonium salt with the amine that is attacked by the 3-position of the thiophene.