The DIBAL has the following structure:
Reaction Mechanism:
Cyclic esters (lactones) reduce with DIBAL to give molecules with aldehyde and alcohol groups.
Reduction of esters to aldehydes: DIBAL
- Details
- Germán Fernández
- ESTERS THEORY
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Esters are reduced to aldehydes with diisobutylaluminum hydride (DIBAL) at -78°C. A single equivalent must be used to stop the reaction in the aldehyde, avoiding its reduction to alcohol.